Research Information System University of Greifswald

Steinmetz A*^1,2, Bahlmann S², Bergelt C³, Bröker B⁴, Ewert R⁵, Felix S⁵, Flöel A⁶, Fleischmann R⁶, Hoffmann W⁷, Holtfreter S⁴, Nauck M⁸, Riemann K⁸, Scheer C⁹, Stahl D⁷, Vogelgesang A⁶, Völker U¹⁰, Wiesmann U³, Klinger-König J¹¹, Walk R¹¹, Grabe H¹¹, Groß S⁵, Lehnert K⁵, Fielitz J⁵, Dörr M⁵

1 - Physiotherapie Neu

2 - Klinik und Poliklinik für Unfall-, Wiederherstellungschirurgie und Rehabilitative Medizin

3 - Institut für Medizinische Psychologie

4 - Institut für Immunologie und Transfusionsmedizin / Abt. Medizinische Immunologie

5 - Zentrum für Innere Medizin / Klinik für Innere Medizin B

6 - Klinik und Poliklinik für Neurologie

7 - Institut für Community Medicine / Abt. Versorgungsepidemiologie und Community Health

8 - Institut für Klinische Chemie und Laboratoriumsmedizin

9 - Klinik für Anästhesie, Intensiv-, Notfall- und Schmerzmedizin

10 - Interfakultäres Institut für Genetik und Funktionelle Genomforschung / Abt. Funktionelle Genomforschung

11 - Klinik und Poliklinik für Psychiatrie und Psychotherapie

Abstract: (1) Background: COVID-19 is often associated with significant long-term symptoms and disability, i.e., the long/post-COVID syndrome (PCS). Even after presumably mild COVID- 19 infections, an increasing number of patients seek medical help for these long-term sequelae, which can affect various organ systems. The pathogenesis of PCS is not yet understood. Therapy has so far been limited to symptomatic treatment. The Greifswald Post COVID Rehabilitation Study (PoCoRe) aims to follow and deeply phenotype outpatients with PCS in the long term, taking a holistic and comprehensive approach to the analysis of their symptoms, signs and biomarkers. (2) Methods: Post-COVID outpatients are screened for symptoms in different organ systems with a standardized medical history, clinical examination, various questionnaires as well as physical and cardiopulmonary function tests. In addition, biomaterials are collected for the analysis of immunomodulators, cytokines, chemokines, proteome patterns as well as specific (auto)antibodies. Patients are treated according to their individual needs, adhering to the current standard of care. PoCoRe’s overall aim is to optimize diagnostics and therapy in PCS patients.